Friday, March 23, 2018
Sunday, March 11, 2018
PSMA targeted therapies, information about
01. German PSMA theraputics .here. Ligands for Imaging and Therapy
02. Google search on psma ligand .here.
other things to engage PSMA receptors in the salivary glands, possibly?
03. 2017 Review article, Japan, alpha particle therapy .here.
04. Trial NCT03276572 Cornell, Weil, NYC, Dr.Tagawa 225Ac
91. NCT02913196 - apalutamide trial in MCRPC & chemo
==GERMANY Treatment Heidelberg 177Lu==
Treatment: alpha particles + PSMA, PubMed article .here.
Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
clemens.kratochwil@med.uni-heidelberg.de
University Hospital Heidelberg ( .here. ) Markus Hohenfellner, M.D.
Friday, March 2, 2018
Questions, questions
01. The Androgen Receptor(AR) is coded for in DNA. At some point after cell division, the prostate cell makes more ARs. Does free testosterone in the nucleus either block or enhance the expression of ARs? How do the AR genes get expressed?
02. Can one mRNA express a gene more than once? Be translated by more than one ribosome?
03. A study concludes that raising the concentrtation of T in the blood may not raise the concentration of T in the cytoplasm. Doe this mean that diffusion is not the only way that T crosses the cell wall?
04. What is the "PSA" reading of fluid inside a healthy prostate cell.
05. In healthy men, the concentration of PSA in the gland is higher than the concentration of PSA in the blood. Does that mean that the rise in PSA is due in part to leakage; to a plumbing problem?
06. What is the role of Testosterone in mitosis?
07. If people have no idea how Provenge works, why do they think it does work, rather than think it hurts older people in the control group who have their white blood cells extracted, and not replaced?
08. Is there a reason that prostate cancer metastasizes to the strongholds of the immune system: lymph nodes and bone marrow?
09. ARv7 is the dangerous variant because it is active without Testosterone. Is it because of over expression of some gene? What gene is dangerously over expressed?
10. When AR dimerizes, can dissimmilar splice variants form a dimmer?
11. Does dimerization occur outside the nucleus?
12. Is the DNA binding region a theraputic target? How many variations are there to the DNA binding region on the AR?
13. Hormone response elements are binding sites on the DNA. Name for DNA spool: histone
14. PSA. The "A" stands for antigen. Does it create an immune reaction? Are there antibodies?
15. Apparently genes can be coded on either strand(?). sense/anti-sense
16. Detection of stem cells: 1.In Dallas 2.In Korea
17. There are two isoforms of the Androgen Receptor, alpha and beta. What is the difference?
18. What is the role of the estrogen receptor?
02. Can one mRNA express a gene more than once? Be translated by more than one ribosome?
03. A study concludes that raising the concentrtation of T in the blood may not raise the concentration of T in the cytoplasm. Doe this mean that diffusion is not the only way that T crosses the cell wall?
04. What is the "PSA" reading of fluid inside a healthy prostate cell.
05. In healthy men, the concentration of PSA in the gland is higher than the concentration of PSA in the blood. Does that mean that the rise in PSA is due in part to leakage; to a plumbing problem?
06. What is the role of Testosterone in mitosis?
07. If people have no idea how Provenge works, why do they think it does work, rather than think it hurts older people in the control group who have their white blood cells extracted, and not replaced?
08. Is there a reason that prostate cancer metastasizes to the strongholds of the immune system: lymph nodes and bone marrow?
09. ARv7 is the dangerous variant because it is active without Testosterone. Is it because of over expression of some gene? What gene is dangerously over expressed?
10. When AR dimerizes, can dissimmilar splice variants form a dimmer?
11. Does dimerization occur outside the nucleus?
12. Is the DNA binding region a theraputic target? How many variations are there to the DNA binding region on the AR?
13. Hormone response elements are binding sites on the DNA. Name for DNA spool: histone
14. PSA. The "A" stands for antigen. Does it create an immune reaction? Are there antibodies?
15. Apparently genes can be coded on either strand(?). sense/anti-sense
16. Detection of stem cells: 1.In Dallas 2.In Korea
17. There are two isoforms of the Androgen Receptor, alpha and beta. What is the difference?
18. What is the role of the estrogen receptor?
Friday, February 10, 2017
Tuesday, October 25, 2016
Wednesday, September 7, 2016
Videos
Bruce Hollis on Vitamin D (5000 units/day)
https://youtu.be/QrU1yrmNIqc
Treating metastatic prostate cancer
Imaging technologies, Phoenix
Dr Mark Emberton, London. Killing tissue is not the difficult part.
Vitamin D
Treating metastatic prostate cacner
Dr Datoli and seeds plus radiation
Dr Antonarakis and V7 (JOhns Hopkins)
Dr Denmeade (big on BAT) but this is other than that (Johns Hopkins)
a short talk on receptors
A pal of Snuffy Myers
Scanning
Sunday, August 21, 2016
Articles about Cancer
0) causes
-- causes can be discrete or continuous
-- discrete: the presence or absence of something
-- continuous: too much or too little
1) Testosterone:
-- Testosterone can be too low
-- Testosterone helps create EPO for blood
-- women's levels are 10% of mens, so instead of 350 they have 35.
-- Why is 0 the goal for testosterone?
2) PSA:
3) Estrogen:
4) ADT:
5) Bones
-- bone fracture is not that immediate a problem
-- the danger is to bone marrow and blood creation
6) Immune system:
7) prostate cells
-- kill all the prostate cells, healthy and sick
8) Side effects
-- osteoporosis - fix is estrogen
-- hot flashes - fix is estrogen
PubMed
1. Isaacs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374010/
2.
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