Questions, questions

01. The Androgen Receptor(AR) is coded for in DNA. At some point after cell division, the prostate cell makes more ARs. Does free testosterone in the nucleus either block or enhance the expression of ARs? How do the AR genes get expressed?
02. Can one mRNA express a gene more than once? Be translated by more than one ribosome?
03. A study concludes that raising the concentrtation of T in the blood may not raise the concentration of T in the cytoplasm. Doe this mean that diffusion is not the only way that T crosses the cell wall?
04. What is the "PSA" reading of fluid inside a healthy prostate cell.
05. In healthy men, the concentration of PSA in the gland is higher than the concentration of PSA in the blood. Does that mean that the rise in PSA is due in part to leakage; to a plumbing problem?
06. What is the role of Testosterone in mitosis?
07. If people have no idea how Provenge works, why do they think it does work, rather than think it hurts older people in the control group who have their white blood cells extracted, and not replaced?
08. Is there a reason that prostate cancer metastasizes to the strongholds of the immune system: lymph nodes and bone marrow?
09. ARv7 is the dangerous variant because it is active without Testosterone. Is it because of over expression of some gene? What gene is dangerously over expressed?
10. When AR dimerizes, can dissimmilar splice variants form a dimmer?
11. Does dimerization occur outside the nucleus?
12. Is the DNA binding region a theraputic target? How many variations are there to the DNA binding region on the AR?
13. Hormone response elements are binding sites on the DNA. Name for DNA spool: histone
14. PSA. The "A" stands for antigen. Does it create an immune reaction? Are there antibodies?
15. Apparently genes can be coded on either strand(?). sense/anti-sense
16. Detection of stem cells: 1.In Dallas 2.In Korea
17. There are two isoforms of the Androgen Receptor, alpha and beta. What is the difference?
18. What is the role of the estrogen receptor?